New study proves that COVID-19 is far more harmful and deadly than the flu

Since the beginning of the COVID-19 pandemic, one of the essential talking points of the far-right globally has been that SARS-CoV-2, the virus that causes COVID-19, is no more harmful than the seasonal flu. From former Brazilian President Jair Bolsonaro calling COVID-19 a “little flu,” to Donald Trump claiming in February 2020 that the virus would be seasonal and “miraculously” disappear by Easter, this propaganda campaign aimed to minimize the dangers posed by COVID-19 and condition society to “live with” COVID-19 and all other pathogens.

With over 27 million excess deaths attributable to COVID-19 and estimates that hundreds of millions of people are now suffering from Long COVID-19 worldwide, such a comparison with the flu was always a transparent falsehood. Still, the propaganda has had an impact on public consciousness, with the great mass of the population unaware of the ongoing dangers they face as new variants of SARS-CoV-2 evolve and sweep across the globe every few months, leaving in their wake ever-growing numbers of dead and disabled.

While many principled scientists have exposed this central falsehood of the pandemic, none have done so as comprehensively as a study published last Thursday by the team of researchers led by Dr. Ziyad Al-Aly, the director of the Clinical Epidemiology Center, chief of research and development service at the Veterans Affairs (VA) Saint Louis Health Care System.

Dr. Al-Aly at his desk [Photo by Dr. Ziyad Al-Aly]

The study, published in the Infectious Disease section of the Lancet, is an 18-month comparative analysis following patients after hospital admission for COVID-19 versus influenza. It proves definitively that not only is COVID-19 far deadlier than influenza, but it also causes more long-term health injuries and damage to the body.

While this was not the authors’ intention, the study also provides the first measurable comprehensive assessment of the long-term health complications of influenza, what is known as “Long Flu,” which are considerable.

Event rates per 100 persons are presented for COVID-19 (red) and seasonal influenza (blue). The hazard ratio, rate, and rate difference per 100 persons during the periods of 0–30, 0–180, 0–360 and 0–540 days are also presented. [Photo: Yan Xie,Taeyoung Choi,Ziyad Al-Aly]

Similar to infection with SARS-CoV-2 and a slew of other pathogens such as measles, Epstein-Barr virus, herpes, and other coronaviruses, the influenza virus too can cause long-term health complications after the acute phase of the infection has subsided. This phenomenon was already known to some extent by the historical record of the 1918 influenza pandemic, but until now there had been very little quantitative data on “Long Flu.”

Senior author Al-Aly said in a news release by the Washington University School of Medicine in St. Louis, “The study illustrates the high toll of death and loss of health following hospitalization with either COVID-19 or seasonal influenza. It is critical to note that the health risks were higher after the first 30 days of infection. Many people think they’re over COVID-19 or the flu after being discharged from the hospital. That may be true for some people. But our research shows that both viruses can cause long-haul illness.”

This latest study by Al-Aly’s team, which is responsible for some of the most pioneering research on the impacts of COVID-19, is very timely. The US and much of the world are presently in the grips of a massive winter wave of infections caused by the highly infectious and immune-resistant Omicron JN.1 subvariant. In multiple countries where JN.1 is already dominant, most significantly in Singapore which has very high vaccination rates, COVID-19 hospitalizations are beginning to rise dramatically.

Utilizing the VA’s vast database, the study authors included over 82,000 patients who had been admitted for COVID-19 between March 1, 2020, and June 30, 2022, encompassing the pre-Delta, Delta, and Omicron phases of the pandemic. However, because of influenza’s rarity in the US during this period when some semblance of mitigation measures remained in place to combat COVID-19, the authors resorted to using a historical cohort (between October 1, 2015, and February 28, 2019) of nearly 11,000 influenza patients who had been hospitalized for a comparator.

A total of 94 pre-specified health outcome measures were analyzed, encompassing ten organ systems that included “cardiovascular, coagulation and hematological, fatigue, gastrointestinal, kidney, mental health, metabolic, musculoskeletal, neurological, and pulmonary.” The acute phase of their infections was defined as the first 30 days after their admission to the hospital and the post-acute phase of infection encompassed days 31 to 540, or 18 months.

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